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00:06 Insulin resistance
00:24 Hyperinsulinemia to the rescue
00:48 The other half of the insulin story
01:21 Insulin and fats
01:55 Partnering with the liver
02:12 A starving brain is a goner
02:38 Two cooks spoil the broth
03:02 Freezing liver sugar production
03:34 SREBP1c ignoring orders
04:07 What should happen in insulin resistance
04:16 What does happen in insulin resistance
04:35 Insulin resistance is selective
05:10 Too much fat
05:41 Insulin’s dilemma - spoilt for choice
06:17 Why the “dis-obedience” ?
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.
PNAS (2010) 107 (8) : 3441–3446.
Shijie Li, Michael S. Brown and Joseph L. Goldstein.