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00:14 Cholesterol supersaturated bile
00:37 So logic says : Stop that “high” cholesterol
01:06 Reworking the cholesterol numbers
01:44 Bile is a mixture
02:02 The cholesterol percentage
02:19 Percentage versus concentration
02:49 The concentration of cholesterol
03:11 Cholesterol levels unchanged
03:39 Bile acids were missing
03:56 Multiple studies confirmed the absence of bile acids
04:26 Too much cholesterol is a red herring
04:50 Where have the bile acids gone ?
05:21 Lowering cholesterol won’t fix gallstone disease
Gallbladder bile supersaturated with cholesterol in gallstone patients preferentially develops from shortage of bile acids.
Journal of Lipid Research (2019) 60(3):498-505.
Mats Rudling, Amit Laskar and Sara Straniero